The importance of uniform germination and field emergence for achieving high yields, while ensuring good seed quality, raises the question of the influence of fungicide and insecticide preparations for seed treatment. The aim of this study was to determine the effect of the combination of five insecticides and fungicide preparations on germination energy and germination of four maize inbred lines. The impact of applied preparations on seed quality may vary, depending on the genetic composition of maize inbred lines. Inbred line L-1 was distinguished as the most tolerant, considering the fact that significant differences were not observed in all tested preparations, while the most sensitive genotype, inbred line L-4, showed a significant decrease in germination energy and seed germination when treated with fludioxonil+metalaxyl-M (M), fludioxonil+metalaxyl-M and imidacloprid (M+G), fludioxonil+metalaxyl-M and thiametoxam (M+Cr) and fludioxonil+metalaxyl-M and tefluthrin+thiametoxam (M+FZ). Results of this study indicate the importance of choosing the best combination of pesticides for certain genotypes, in order to ensure full protection of crops and at the same time obtain the high yields.