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The popularity of clustering in segmentation encouraged us to develop a new medical image segmentation system based on two-hybrid clustering techniques. Our medical system provides an accurate detection of brain tumor with minimal time. The hybrid techniques make full use of merits of these clustering techniques and overcome the shortcomings of them. The first is based on K-means and fuzzy C-means (KIFCM). The second is based on K-means and particle swarm optimization (KIPSO). KIFCM helps Fuzzy C-means to overcome the slow convergence speed. KIPSO provides global optimization with less time. It helps K-means to escape from local optima by using particle swarm optimization (PSO). In addition, it helps PSO to reduce the computation time by using K-means. Comparisons were made between the proposed techniques and K-means, Fuzzy C-means, expectation maximization, mean shift, and PSO using three benchmark brain datasets. The results clarify the effectiveness of our second proposed technique (KIPSO).