We retrospectively reviewed clinical and biochemical data of four patients diagnosed with tyrosinaemia type II. Diagnosis was established by high plasma tyrosine and normal plasma phenylalanine levels using plasma high-pressure liquid chromatography and tandem mass spectrometry. All patients were mildly mentally retarded and had painful non-pruritic and hyperkeratotic plaques on the soles and palms. There were no ophthalmic symptoms. The patients dramatically responded clinically and biochemically to a diet restricted in tyrosine and phenylalanine
will be the creation of collective and tacit knowledge that adds the greatest value to an organization [7]. Knowledge management (KM) initiatives that create business value are a major focus for many organizations. While academics often couch KM success in terms of process outcomes, some argue that the organizational outcomes perspective of KM success held by many practitioners is clearer, where KM success is tied to its impact on organizational performance [1,8]. The success or failure of KM depends on how effectively an organization's members share and use their knowledge. Thus management of knowledge is at the core of organization's business growth. In the light of this reflection this special issue pays attention to two main perspectives. First, recognizing that knowledge, likewise any other organization's resource, needs management means to support its allocation and development, the frameworks and tools aiming to identify, manage and assess the critical knowledge resources for growth are focused on. Second, acknowledging that the translation of knowledge into business outcomes requires management mechanisms, and then considering the knowledge processes grounding the improvement of performance [9]. Cader et al. mentioned that successful identification of trends requires continuous implementation of market research as well as investment in research and development-for this will nurture the generation of a sustained stream of competitive and innovative products and services that in turn foster growth and profit [2]. In the
We considered the clinical, biochemical and radiological findings, and response to pyridoxine [vitamin B6]of 24 classic homocystinuric patients [15 females, 9 males]diagnosed at King Faisal Specialist Hospital and Research Centre. Common clinical findings included ectopia lentis [20 patients], skeletal system involvement [18 patients], vascular system involvement [9 patients]and mental retardation [all patients to varying degrees]. A number of unusual findings were reported. The parents of 21 patients were first-degree relatives and 19 patients had at least one other family member affected by the same disease. Only 4 patients responded to pyridoxine; their methionine level decreased to almost normal range
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