Background: Inflammation causes a rise in the levels of certain proteins; these proteins are identified as acute stage proteins and one of these proteins is C-reactive protein (CRP). CRP composed of 206-amino acid of the short pentraxin family. Objective: This review assessed CRP as an inflammatory indicator that has an important role in the host's defense against infection and also it is documented the pivotal role of this protein during infections with different parasites. Conclusion: This review is hypothesizing that CRP levels rise during infections caused by parasites. Other studies revealed that there is no association of soil-transmitted helminths infections with the increasing levels of CRP. Keywords: C-reactive protein; protozoan parasites; soil-transmitted helminths
Atherosclerosis is a condition of the hardening of a blood vessel via the development of plaques around the artery wall which causes the artery to narrow, leading to severe complications. Toxoplasmosis is an opportunistic parasitic infection that causes pathological complications in immunocompromised patients, which lead to increase the burden on the immune system in these patients. This study aims to assess the incidence rate of toxoplasmosis in atherosclerosis patients and its potential to change C - reactive protein (C-RP) and vitamin D3 levels. Serum samples (150) were tested for the positivity of anti-Toxoplasma IgG and IgM antibodies by means of Enzyme-linked immunosorbent assay (ELISA). In addition, C-RP was assessed in all serum samples by means of Latex Fixation Test, while VtD3 was estimated by MiniVidas device. The results revealed that the seroprevalence of toxoplasmosis in atherosclerotic patients was comparatively higher as compared to that in the control group, with significant differences in C-RP and VtD3 levels. These results suggest that the decreased levels of VD3 lead to increase the incidence of T. gondii infection in atherosclerosis patients.
Psoriasis is a common, chronic, immune mediated disorder.The disease is arising as a result of dysregulated interactions of the innate and adaptive immune system in the context of skin epithelium and connective tissue. The biological drug Etanercept(ETN) approved for use in treated psoriasis. ETN is tumor necrosis factor-α (TNF-α) inhibitor. In this study, 48 psoriatic patients were taken before and after treatment who attended to the Dermatology and Venereology Department in Baghdad Teaching Hospital during the period from December 2016 to September 2017and 50 samples were used as healthy control group. The results showed that most psoriatic patients 52.08 % were within the second and third decades 20-35 year, and the majority of psoriatic patients were males 62.5% and the ratio of male to female is 1.67:1. Moreover, the results demonstrated that the males were more expected psoriasis compare with females. Blood samples were collected and TNF-α was estimated in sera of all subjects by using Enzyme Linked Immunosorbent Assay (ELISA). The TNF-α mean levels in psoriatic patients before treatment was 189.5±26.0 ng/ml, and after treatment was 223.6±41.1 ng/ml compar with the healthy control group 93.5±2.4 ng/ml. The results showed significant differences between the studied groups.
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