The aim of this study was to compare the effects of live and recorded lullabies on physiological and behavioural state outcomes of stable preterm infants. We conducted a prospective, repeated measures crossover study, involving 35 stable infants of less than 32 weeks postmenstrual age. Each infant received a different intervention for three consecutive days (live lullabies, recorded lullabies, and no-music sessions). The infant was observed every 5 min for 30 min before, 20 min during, and 30 min after the intervention. The results revealed that the infants' heart rate (HR) decreased significantly for the live and recorded lullabies conditions but not for the control condition (p = .02). The findings also suggest that the live lullabies condition resulted in a deeper sleep than the recorded lullabies condition (p = .02) and the control condition (p = .006). No changes were observed in oxygen saturation level. The results of this study show that lullabies effectively reduce the HR of preterm infants less than 32 weeks postmenstrual age, and live lullabies have a greater beneficial impact on their sleep state than recorded lullabies.
Restrictive dermopathy (RD) is a rare lethal autosomal recessive genodermatosis, characterized by abnormally rigid skin with prominent superficial vasculature, erosions and epidermal hyperkeratosis, dysplastic clavicles, joint contractures, mouth fixed in the 'O' position, small pinched nose, and neonatal death. Mutations of ZMPSTE24 and LMNA genes are reported as the causes of RD, with those of ZMPSTE24 being more prevalent. Here, we report on a familial c.50delA (p.Lys17Serfs*21) mutation of the ZMPSTE24 gene, causing RD in two siblings.
Background: Acute appendicitis in a newborn is rare and may be fatal. The reported incidence is 0,04 % to 0,2 %. Diagnosis remains challenging as the symptoms are undefined.Case presentation: Here we present a full-term newborn boy of 9 days presenting with malaise, reluctance to feed and subfebrile fever. Over the course of 6 days his condition became worse. The newborn was febrile, passed no stool and his stomach became distended. Perforation due to necrotizing enterocolitis was highly suspected. The diagnosis of acute appendicitis was finalized perioperatively after the perforation and worsening condition made the emergency surgery inevitable. After 16 days of admission the patient was discharged in good condition.Conclusion: Appendicitis in neonates is a dangerous yet manageable condition. While rare it should be included in differential diagnosis when presented with atypical necrotizing enterocolitis or unexplained peritonitis. Quick and accurate diagnosis may increase survival rates.
Santrauka. Tikslas. Įvertinti neišnešiotų naujagimių nefrokalcinozės formavimosi rizikos veiksnius. Metodai. Retrospektyvusis tyrimas atliktas Vilniaus universiteto ligoninės Santaros klinikų Neonatologijos centre, analizuoti 2017 m. sausio–spalio mėn. gydytų 77 neišnešiotų naujagimių duomenys. Nefrokalcinozė nustatyta ultragarsiniu tyrimu. Statistinė analizė atlikta SPSS programos 19 versija. Rezultatai. Nefrokalcinozė nustatyta 32,5 proc. atvejų. Didžiausios įtakos (kai p<0,05) nefrokalcinozės rizikai turejo šie veiksniai (tiriamoji ir kontrolinė grupė atitinkamai): mažesnis Apgar įvertis gimus po 1 min. (6,6 ir 7,1) ir po 5 min. (7,9 ir 8,1), gestacinis amžius (27+3 sav ir 28+6 sav.), gimimo svoris (1073,6 g ir 1335,7 g), atviras arterinis latakas (44 proc. ir 13,5 proc.), lėtine plaučių liga (48 proc. ir 17,3 proc.), ilgesnis kvėpuojamosios terapijos poreikis (33,3 dienos ir 20,5 dienos) ir hospitalizacijos trukmė (67 dienos ir 53,8 dienos), didesnis šarminės fosfatazės kiekis kraujo serume (544 U/l ir 443,8 U/l). Išvados. Nefrokalcinozė dažniau formuojasi neišnešiotiems, sunkios buklės naujagimiams, kuriems yra ilgalaikis kvepuojamosios terapijos poreikis ir lėtinė plaučių liga, buklė komplikuojant atviram arteriniam latakui.
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