Bennett et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
With up to 20% of surgical resections for suspected biliary malignancy showing benign final pathology, pancreatobiliary stricture malignancy detection is an area where progress needs to be made. 1 Even with careful clinicopathologic correlation, pancreatobiliary stricture specimens remain a common source of false negatives in general and false positives in primary sclerosing cholangitis (PSC). 1 UroVysion (U-FISH), which was developed for urothelial cancer, is the most commonly used ancillary method for biliary strictures but remains relatively underutilized despite repeated reports that it increases sensitivity. It is a fluorescent in situ hybridization (FISH) assay that uses four probes; 3 pericentromeric probes for chromosomes 3, 7, and 17 as well as a probe for the 9p21 band. 8 Aneuploidy is a near-universal event in solid tumors and >66% show whole chromosome alterations. 30 The chromosomes
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.