Obesity and its associated comorbidities are a major public health concern worldwide. Reduced energy intake and increased physical activity interventions have limited success in the long term. Nutraceuticals might be...
Eficacia de los hidroxicinamatos y los beta-glucanos como herramientas dietéticas frente a la obesidad y sus disfunciones asociadas, y su aplicación como nutracéutico Effectiveness of hydroxycinamates and betaglucans as dietary tools against obesity and its associated dysfunctions, and their application as nutraceuticals 10.20960/nh.03125 rev 3125 Eficacia de los hidroxicinamatos y los beta-glucanos como herramientas dietéticas frente a la obesidad y sus disfunciones asociadas, y su aplicación como nutracéutico Effectiveness of hydroxycinamates and beta-glucans as dietary tools against obesity and its associated dysfunctions, and their application as nutraceuticals
Purpose
This study aimed to assess the effect of dietary consumption of olive pomace oil (OPO) on blood lipids (primary outcome) and other cardiovascular disease (CVD) risk factors (blood pressure, inflammation and endothelial function as secondary outcomes).
Methods
A randomized, controlled, blind, crossover intervention was carried out in healthy and at-risk (hypercholesterolemic) subjects. Participants consumed daily 45 g of OPO or high-oleic acid sunflower oil (HOSO) as control oil during 4 weeks.
Results
OPO significantly reduced low-density lipoprotein cholesterol (LDL-C; P = 0.003) and apolipoprotein B (Apo B; P = 0.022) serum concentrations, and LDL/HDL ratio (P = 0.027) in healthy and at-risk volunteers. These effects were not observed with HOSO. Blood pressure, peripheral artery tonometry (PAT), endothelial function and inflammation biomarkers were not affected.
Conclusions
Regular consumption of OPO in the diet could have hypolipidemic actions in subjects at cardiovascular risk as well as in healthy consumers, contributing to CVD prevention.
Clinical trial registry
NCT04997122, August 8, 2021, retrospectively registered.
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