Pre-eclampsia is a multifactorial and multisystemic disease of unknown etiology that constitutes an important cause of maternal and perinatal morbidity and mortality. 1 Worldwide, 76 000 women and 500 000 newborns die each year as a result of pre-eclampsia.Furthermore, women in low-income countries are at a higher risk of developing this disease compared with those in high-income countries. 2 Pre-eclampsia is a placental disease, with a wide range of symptoms arising from a decrease in organic perfusion related to endothelial activation and vasospasm. 3 Pre-eclampsia has been defined as de novo arterial hypertension after 20 weeks of gestation, associated with any of the following manifestations: proteinuria, maternal organic dysfunction (renal, hepatic, neurologic, and hematologic) and uteroplacental dysfunction. 4,5 Pre-eclampsia is classified on clinical-analytical characteristics as mild pre-eclampsia: blood pressure (BP) at least 140/90 mmHg
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