Mycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to these compounds. In the present study, M. vaccae cells adapted to these compounds mainly by making adjustments in their lipid composition and net surface charge. The modifications in the lipid composition led to changes in membrane permeability which resulted in increased tolerance towards levofloxacin, thioridazine, and omeprazole.
Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. //dx.doi.org/10.17058/reci.v7i1.7380 Páginas 01 de 06 não para fins de citação Background and Objectives: Uniforms worn by professionals that have access to the Intensive Care Units (ICU) may contain bacteria resistant to different drugs and, therefore, it is of utmost importance to determine whether they carry microorganisms that are possibly pathogenic to patients and other professionals who work in these units. The study aimed to identify, through microbiological analysis, all microorganisms found in the private uniforms of professionals working in the ICU, to make a comparative analysis of bacterial growth in the samples collected at the beginning and the end of the study and verify the sensitivity profile of samples positive for Staphylococcus aureus. Methods: This is a cross-sectional study based on sample collection from uniforms worn by professionals working in the three ICUs of a large public hospital. These collections were performed before and after being worn in the work environment. Cultures and antimicrobial sensitivity tests were performed. Results: After the microbiological analyses, we observed a 154% increase in the number of colonies when comparing the colonization of the initial samples with the final ones; among the identified microorganisms, there was a predominance of coagulase-negative Staphylococcus (72.8%) followed by S. aureus (38.4%). The latter showed sensitivity to oxacillin of RESUMO ABSTRACT ARTIGO ORIGINAL Contaminação de uniformes privativos utilizados por profissionais que atuam nas unidades de terapia intensivaPrivate uniform contamination of healthcare professionals working in intensive care units Justificativa e Objetivos: Os uniformes utilizados para o acesso as Unidades de Terapia Intensiva (UTI) podem conter bactérias resistentes a diferentes drogas, devido a isso é de grande importância verificar se estes estão carreando microrganismos possivelmente patogênicos aos pacientes e demais profissionais que trabalham nestas unidades. Neste sentido o objetivo deste estudo foi identificar, por meio da análise microbiológica, os microrganismos presentes nos uniformes privativos de profissionais que atuam nas UTI, realizar uma análise comparativa de crescimento bacteriano nas amostras coletadas no início e fim de trabalho e verificar o perfil de sensibilidade das amostras positivas para Staphylococcus aureus. Métodos: Trata-se de um estudo transversal realizado a partir da coleta de amostra dos uniformes utilizados por profissionais que trabalham nas três UTI de um hospital público de grande porte, essas coletas foram realizados antes e após serem utilizadas no ambiente de trabalho. Foram realizados cultura e teste de sensibilidade aos antimicrobianos. Resultados: Depois das análises microbiológicas foi possível observar um aumento no número de colônias de 154% quando comparada a colonização das amostras iniciais com as amostras fin...
Meningitis is an inflammatory process of the brain membranes and cerebrospinal fluid (CSF) that surrounds the nervous system and may be caused by factors of an infectious or noninfectious nature. Thus, the aim of this study is to trace the epidemiological profile of meningitis in the State of Pará from 2015 to 2018. This is a descriptive, retrospective study and was used as information sources the Information System of Notification of Disorders, whose data are available from the SUS Department of Informatics. The data obtained were organized in Microsoft® Excel 2016 spreadsheets, where they were analyzed by making graphs and tables. From January 2015 to December 2018 1974 cases of Meningitis were reported in the State of Pará. In 2017 there were a higher number of reported cases (n 509) compared to the other years evaluated. The age group most affected by the disease was between 20-39 years old, representing approximately 34% (n 678) of confirmed cases and the etiology of meningitis cases may vary between age groups. Therefore, it is necessary for the population to disclose the means of preventing the disease and its correct management in suspected cases, in order to avoid as many sequelae as possible, in addition to reinforcing the importance of notification to the Epidemiological Surveillance to enable the application of combat strategies. the disease.
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