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ABSTRACT:We report a case of fatal intoxication from 1,4-butanediol (1,4-BD), which was ingested by a young and "na€ ıve" gammahydroxybutyrate (GHB) consumer during a party with the co-ingestion of alcohol, cannabis, and methylene-dioxy-methamphetamine. The following drug concentrations were found using gas chromatography coupled with mass spectrometry on autopsy samples and on a cup and a glass found at the scene: 20,350 mg/L (bottle) for 1,4-BD; 1020 mg/L (femoral blood), 3380 mg/L (cardiac blood), 47,280 mg/L (gastric content), and 570 mg/L (vitreous humor) for GHB. The concentration of GHB is difficult to interpret in forensic cases due to the possibility of an endogenous production of GHB. The variable tolerance of the user may also modify the peri-and postmortem GHB concentrations. This case underscores the need to have many different sources of toxicology samples analyzed to avoid the hypothesis of endogenous production of GHB.

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Non-forensic autopsies are in decline, particularly in the case of deaths outside hospital, despite the fact that they are a crucial consideration for screening among relatives of a person who died sud!denly. The findings suggest that there needs to be an improvement in practice, a fact made possible by recent legislative developlments in France. A number of initiatives have been successful arId give hope that, like the reference centers specializing in unexpected infant deaths, reference centers specializing in sudden de'aths, which allow for more systematic non-forensic autopsies ofadults who die suddenly, might be created.

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