A method of RhII‐catalyzed C−H carboxylation of 2‐(imidazo[1,2‐a]pyridin‐2‐yl)phenols via CO2 fixation under redox‐neutral conditions was reported, providing an access to a range of coumarin derivatives. A suitable diphosphine ligand was crucial for this reaction. This reaction could be performed under relatively lower temperature or in a shorter time than the alternative base‐promoted protocol.
The first non-directed dehydrogenative phenone coupling method of methylarenes with aromatic CÀ H bonds, displaying a large substrate scope, is herein reported. This reaction represents a far more direct atom-and step-efficient alternative to the classical Friedel-Crafts or Suzuki-Miyaura derived acylation reactions. The method can be carried out on a gram scale and was successfully applied to the synthesis of several Ketoprofen drug analogues.
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