A route for the synthesis of 2-methylfurobenzopyranone by the oxidative cyclization of sodium salt of 7-hydroxy-6 or 8-allyl-4H-[1]benzopyran-4-one using PdCl2(PhCN)2 complex has been developed.
A convenient and simple method for the synthesis of novel 3,4‐dihydrofuran‐annulated coumarins, 3‐(hydroxymethyl)‐2H‐furo[3,2‐c]chromen‐4(3H)‐ones 5a, 5b, 5c, 5d, 5e, 5f, 5g, by combined Claisen rearrangement and intramolecular regioselective oxidative cyclization of 4‐O‐allyl coumarin intermediates 3a, 3b, 3c, 3d, 3e, 3f, 3g using inexpensive oxidizing agent m‐CPBA is described. The reaction proceeds smoothly by tandem epoxidation/regioselective 5‐exo‐tet‐intramolecular ring opening. The structures of synthesized compounds are established on the basis of spectral data including IR, 1H NMR, and mass and elemental analyses.
In our efforts to propose, Praseodymium (III) metal complex derived from 5-Bromo-2-hydroxybenzyl-2-furyl methyl for the biological efficacy. The structure of the synthesized imine and complex has been characterized by UV, IR, Mass, 1 H and 13 C NMR. The ligand and the metal complex carried for their anti-microbial tendency to control the disease-causing pathogens such as Escherichia coli, Klebsiella pneumonia, Salmonella typhimurium, Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus. The derived metal complex exhibited better result and is additional effective bactericides than the ligand.
Combined Claisen Rearrangement and Oxidative Cyclization as a Route to Hydroxymethyl Dihydrofuran-Annulated Coumarins. -The title compounds are efficiently and conveniently obtained by a tandem epoxidation/5-exo-tet intramolecular ring opening of allyl-derivatives (I) using MCPBA as inexpensive oxidizing reagent. -(JAYAPRAKASH*, R. Y.; CHAKRAVARTHULA, V.; J. Heterocycl. Chem. 52 (2015) 4, 1014-1018, http://dx.
Condensation of 8-formyl-7-hydroxy chromones 2a -e with methyl vinyl ketone and acrylonitrile in the presence of diazabicyclo[2.2.2]octane (DABCO) under Baylis-Hillman reaction conditions afforded 9-cyano/acetyl-substituted pyrano[2,3f ]chromones 3a -e and 4a -e .
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