A B S T R A C T BACKGROUNDOxidative stress has an important role in precipitating diabetes mellitus by increasing production of reactive oxygen species and decreasing endogenous antioxidants. Free radicals are produced by cellular metabolism and are known for both beneficial and deleterious effects. Various antioxidants control the biological effects of these free radicals. Obesity is one of the major risk factors for diabetes and diabetes is emerging as the king of all diseases, is a major threat to health worldwide. The prevalence of type II diabetes mellitus among first degree relatives of patients with the condition is significantly higher than in the general population. Aim of present study is to compare the oxidative stress in persons with type II diabetes mellitus with and without family history of diabetes mellitus. METHODSThis is a cross sectional study. Type II diabetes mellitus cases 32 -70 years of age who attended OPD, Department of General Medicine, G.S.L. General Hospital, Rajahmundry, Andhra Pradesh, were selected. The study participants were divided into two groups viz. group 1 with family history of diabetes (n= 193) and group 2 without family history of diabetes (n= 107). Study period was from 1 st January 2016 to 31 st December 2016. Oxidative stress levels were compared in the above said groups by measuring serum glutathione by Ellman's reaction and total antioxidant capacity of plasma by FRAP assay. Other parameters measured were BMI, FPG and whole blood HbA1c. RESULTSSignificant difference between whole blood HbA1c, serum glutathione & total antioxidant capacity were observed (p < 0.0001) between the two groups. BMI (p= 0.88) and FPG (p= 0.48) however did not show any significance. CONCLUSIONSDecreased antioxidant levels and increased oxidative stress in cases with negative family history of diabetes suggest the role of stress in precipitating type II diabetes mellitus.
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