Introduction. The Portuguese lung transplant program was started in 2001. Since then, it is coordinated by the Lung Transplant Centre of the Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, the only lung transplant centre in the country. Eight years after its start, a major reorganization of the program and the teams involved, resulted in a significant improvement in hospitals' response capacity. Methods. Retrospective analysis of the clinical files of the 90 patients treated between January 2009 and July 2015. 9 patients were excluded because of missing data. Eighty one patients were included. Collected data included demographic variables, type of transplant, pre-transplant diagnosis, duration of anaesthetic procedure, type of circulatory support, blood product transfusion requirements, hospital stay and 3 month mortality. Results. A clear enhancement of surgical activity has been seen over the years, from 8 cases of 2009 to 18 cases in 2014. From January to July 2015 we had already 8 cases. In demographic analysis, 45 (55,6%) patients were male and 36 (44,4%) were female with a mean age of 46,1Ϯ13,19 years. The six most common pre-transplant diagnosis, responsible for more than 80% of the cases, were: pulmonary fibrosis (n¼14), extrinsic allergic alveolitis (n¼13), COPD (n¼13), cystic fibrosis (n¼11), alpha-1 antitrypsin deficiency (n¼9) and bronchiectasis (n¼7). In fifty one cases (63%) was performed single lung transplant and in 30 cases (37%) was performed double lung transplant. Average time for the anaesthetic procedure was 719,33Ϯ172,1 minutes for double lung transplant and 515,98Ϯ135,6 minutes for single lung transplant. No cardiopulmonary support was used in 62 (76,5%) patients. Conventional cardiopulmonary bypass was used in 10 (12,3%) patients and ECMO in the remaining 9 (11,1%) patients. Average number of transfused blood products was 2,21Ϯ2,96 units for packed red blood cells and 1,57Ϯ1,89 units of fresh frozen plasma. In 73 cases no platelets were used, and the maximum administered were 2 units in only 1 case. Total fibrinogen administration was 5gr. Postoperatively, median time for mechanical ventilation, ICU stay and hospital length of stay was 4, 26 and 41 days, respectively. Overall survival rate at the 3 month was 91,4%. Discussion. This is a retrospective analysis of the data from the only Lung Transplant Centre in Portugal. Lung transplant remains the last resource for patients with end-stage chronic pulmonary disease. Thanks to a multidisciplinary dedicated team, our Centre results pair with the published literature1.