Efficient synthesis of 7‐(1H‐1,2,3‐triazol‐1‐yl)‐4‐trifluoromethyl‐2H‐pyrimido[1,2‐b]pyridazin‐2‐ones from 7‐chloro‐4‐trifluoromethylpyrimido[1,2‐b]pyridazin‐2‐one by a consecutive SNAr reaction with azide, followed by copper‐catalyzed [3+2] cycloaddition is described.
The selective introduction of fluoroalkylated vinylmetals in controlled strategies is a challenging process for many chemists. This study reports the highly regio- and stereoselective synthesis of functionalized vinylgermanes bearing a perfluoroalkyl group from perfluoroalkylated acetylenic esters via AlCl3-catalyzed hydrogermylation. Regio- and stereoselectivity are highly dependent on the nature of the catalyst and the nature of the fluoroalkyl group of alkyne.
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