Schizophrenia (SCZ) treatment is essentially limited to the use of typical or atypical antipsychotic drugs, which suppress the main symptoms of this mental disorder. Metabolic syndrome is often reported in patients with SCZ under long-term drug treatment, but little is known about the alteration of lipid metabolism induced by antipsychotic use. In this study, we evaluated the blood serum lipids of a validated animal model for SCZ (Spontaneously Hypertensive Rat, SHR), and a normal control rat strain (Normotensive Wistar Rat, NWR), after long-term treatment (30 days) with typical haloperidol (HAL) or atypical clozapine (CLZ) antipsychotics. Moreover, psychostimulants, amphetamine (AMPH) or lisdexamfetamine (LSDX), were administered to NWR animals aiming to mimic the human first episode of psychosis, and the effects on serum lipids were also evaluated. Discrepancies in lipids between SHR and NWR animals, which included increased total lipids and decreased phospholipids in SHR compared with NWR, were similar to the differences previously reported for SCZ patients relative to healthy controls. Administration of psychostimulants in NWR decreased omega-3, which was also decreased in the first episode of psychosis of SCZ. Moreover, choline glycerophospholipids allowed us to distinguish the effects of CLZ in SHR. Thus, changes in the lipid metabolism in SHR seem to be reversed by the long-term treatment with the atypical antipsychotic CLZ, which was under the same condition described to reverse the SCZ-like endophenotypes of this validated animal model for SCZ. These data open new insights for understanding the potential influence of the treatment with typical or atypical antipsychotics on circulating lipids. This may represent an outcome effect from metabolic pathways that regulate lipids synthesis and breakdown, which may be reflecting a cell lipids dysfunction in SCZ.
Schizophrenia is a very severe and uncurable brain illness that has affected people throughout history. Medical treatments focus on eliminating the symptoms of this illness and count on use of different antipsychotic medications. It is assumed that this illness can be caused by several factors among which stands altered brain chemistry. This work aims to correlate the composition of lipids isolated from the serum samples of animals used as model animals for schizophrenia and also reveal the antipsychotic drug effects on lipidomics. For these, four groups of animals (Wistar mice) were used: healthy, drug-treated healthy, schizophrenia model and drug-treated schizophrenia model. Total lipids were extracted and analyzed with Nuclear Magnetic Resonance (1 H NMR) and chemometrics.
Nanostructured drug delivery systems are formulations containing particles usually fabricated with polymers. They can be administered by all drug routes (depending on their characteristics) and in various pharmaceutical forms, including nanoemulsions, nanosuspensions, nanofilms and lyophilized powders. The size, shape and surface load influence the functionality of nanoparticles, as well as their stability.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.