Objective To assess the contraceptive efficacy, user acceptability, cycle control, and tolerability of a combined contraceptive vaginal ring for up to 13 cycles. Materials and Methods Healthy women coming to the OPD for contraceptive advice were enrolled in this oneyear study. Each ring was used for three weeks followed by a one-week ring-free period. Results A total of 184 women started treatment forming the intent to treat population. Subjects were followed for 13 cycles. Compliance was good with 99 % of cycles in full compliance with specified criteria. In the intent to treat population, no pregnancies occurred giving a Pearl Index of 0. The mean incidence of withdrawal bleeding was 99 % in all cycles. There was 0.16 % incidence of intermenstrual bleeding and 2 % incidence of early withdrawal bleeding. The ring was well tolerated with a low incidence of adverse events. Conclusion The ring is an effective contraceptive that is convenient, well tolerated with excellent cycle control, and highly acceptable to users.
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