Background: Invasive lobular carcinoma (ILC) comprises 5-16% of all breast cancers, with its incidence gradually increasing. ILC has a disproportionately higher incidence of spread to the gastrointestinal (GI) system.
Methods:This study is a retrospective chart review of all cases of ILC with gastrointestinal metastases seen at a university affiliated tertiary cancer institute between 2005 and 2010, examining demographic, epidemiological, medical, and treatment factors that may have an association with the risk of GI metastases.Results: 343 consecutive cases of lobular breast cancer were reviewed, and 21(6%) were found to have GI metastases. The mean age at initial diagnosis of primary tumor was 63 years. Stages at presentation of the breast primary were: Stages 1/2% =73% and stages 3/4 =27%. Receptor status of the primary breast cancer was as follows: HER2 + =5%, PR + =76%, ER + =90%. The mean age at time of diagnosis of metastatic disease was 67 years. The main presenting symptoms of GI metastatic disease were: incidental finding/asymptomatic (20%), nausea (20%), and abdominal pain (15%). The major sites of extrahepatic gastrointestinal spread were the stomach (52%), peritoneum (38%), and omentum (19%). Average five-year survival from initial diagnosis of ILC was 46%. Five-year survival from diagnosis of gastrointestinal metastasis was 29%.Conclusions: Approximately 1 in 20 patients diagnosed with ILC will have spread to the GI tract, presenting 4 years after their initial primary diagnosis. Future research is needed in http://dx.
Background:
Physicians' well-being is crucial for recruitment and retention in the medical profession. This study aims to identify the prevalence of chronic disease and associated risk factors among residents in Saudi residency programs.
Methods
A cross-sectional study with more than 370 participants was conducted between February 2021 and January 2022. Data were collected through an English-language self-administered online questionnaire.
Results
The most frequently reported chronic health problems were hypertension, diabetes mellitus, and gastrointestinal diseases, primarily associated with residency-related stress and workload. The stress and isolation that residents experience may cause health and emotional disturbances. Less than half of the participating residents reported a family history of chronic disease.
Conclusion
This study reveals the essential need for health care providers to assess their struggles, which affect them directly and impact patients indirectly and seek a suitable solution for those challenges.
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