The algorithms perform favorably compared with a visual inspection of the complete trend. Further research is needed to identify when and how to draw the clinician's attention to these changes.
The synthesis of a series of azole antifungal compounds which incorporate the aminimide functional moiety is described. The procedure involves the reaction of an epoxide intermediate with 1,1‐disubstituted hydrazines to form aminimines which are subsequently treated with acyl chlorides resulting in the desired zwitterionic aminimides. The aminimides were tested for in vitro antifungal activity and found to be moderately active against Candida and Cryptococcus species, but inactive versus Aspergillus.
The Synthesis of Aminimide-Containing Azole Antifungals.-Azole antifungals such as (V) and (VII) are moderately active against Candida and Cryptococcus species, but inactive versus Aspergillus. Aminimide (Vb) is the most potent derivative synthesized. -(ABEL, M. D.; HEWGILL, R. T.; MALCZYK, K. J.; MICETICH, R. G.; DANESHTALAB, M.; J. Heterocycl.
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