Our results indicated that following TBI, there is a substantial increase in angiogenesis and based on morphologic characterization of BrdU-positive nuclei within the endothelium, we provide evidence for vasculogenesis following injury.
TBI causes significant impairments in cognition. These deficits can be ameliorated using a pre-conditioning paradigm. While the precise mechanism has yet to be elucidated, our results indicate that angiogenesis may underlie the cognitive sparing seen in pre-conditioned animals.
Cp migration from cytoskeletal to contractile regions of SM supports its role both in the initiation of vessel contractility and its interaction with cytoskeletal structures subjacent to the cell membrane in SM's contracted state.
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