The findings show that the SLM and the IO are facilitated in neutral lordotic sitting postures and exhibit FRP at mid range flexion while moving from upright sitting to slump sitting. These findings show that FRP in sitting differs from that in standing. Variable motor patterns (activation or FRP) of the TES were observed. These findings suggest that sustaining mid to end-range flexed sitting spinal postures result in relaxation of the spinal stabilizing muscles.

Prior work using lipid-based affinity matrices has been done to investigate distinct sets of lipid-binding proteins, and one series of experiments has proven successful in mammalian cells for the proteome-wide identification of lipid-binding proteins. However, most lipid-based proteomics screens require scaled up sample preparation, are often composed of multiple cell types, and are not adapted for simultaneous signal transduction studies. Herein we provide a chemical proteomics strategy that uses cleavable lipid "baits" with broad applicability to diverse biological samples. The novel baits were designed to avoid preparative steps to allow functional proteomics studies when the biological source is a limiting factor. Validation of the chemical baits was first confirmed by the selective isolation of several known endogenous phosphatidylinositol 3-kinase signaling proteins using primary bone marrow-derived macrophages. The use of this technique for cellular proteomics and MS/MS analysis was then demonstrated by the identification of known and potential novel lipid-binding proteins that was confirmed in vitro for several proteins by direct lipid-protein interactions. Further to the identification, the method is also compatible with subsequent signal transduction studies, notably for protein kinase profiling of the isolated lipidbound protein complexes. Taken together, this integration of minimal scale proteomics, lipid chemistry, and activity-based readouts provides a significant advancement in the ability to identify and study the lipid proteome of single, relevant cell types.

Physiotherapists' participation in physiotherapy students' clinical education varied widely among Ontario regions. Future research could explore whether regional differences are persistent, why they occur, and whether they should be reduced.

Purpose: To describe how often the 24 performance criteria of the Physical Therapist Clinical Performance Instrument (PT-CPI) were not observed and how often they were rated exceptionally well for physical therapy (PT) students in relation to clinical placement descriptors. Methods: Indicators of ''not observed,'' performance ''with distinction,'' and ''significant concerns'' were tabulated from 1,460 clinical placements between 2008 and 2012. The rates for these indicators were evaluated with respect to catchment area, practice setting (hospital/institutional or community-based), practice area (musculoskeletal, cardiorespiratory, neurology, paediatrics, geriatrics, or variety), and level (junior to senior). Results: Of the 24 PT-CPI criteria, 15 had observation rates >95%. Of the other nine criteria, some showed significant differences in observation rates across level, practice setting, and practice area. Ratings of ''with distinction'' were awarded most often for criteria related to professionalism and communication and were awarded more often in community-based settings than in hospital/institutional settings. For some criteria, ''with distinction'' was awarded more often in paediatrics placements than in other areas. The ''significant concerns'' checkboxes were rarely used. Conclusions: The overall observation rates were very similar to those reported elsewhere. The findings related to performance ''with distinction'' and observation rates relative to setting and practice area are new contributions to physical therapy knowledge.Key Words: clinical competence; educational measurement; students; therapy; education, professional. RÉ SUMÉObjectif : Dé crire la fré quence à laquelle les 24 critè res de rendement de l'Instrument d'é valuation du rendement clinique des physiothé rapeutes (ERC-PT) n'ont pas é té observé s et la fré quence à laquelle ils ont obtenu une note exceptionnellement é levé e pour les é tudiants en physiothé rapie en fonction des descripteurs des stages cliniques. Mé thodes : Les indicateurs de « non-observation » et de rendement « avec distinction » et « avec pré occupations importantes » ont é té mis en tableau pour 1 460 stages cliniques de 2008 à 2012. Les taux pour ces indicateurs ont é té é valué s en fonction de l'aire de recrutement, du contexte de pratique (à l'hô pital/en é tablissement ou dans la collectivité ), du domaine de pratique (appareil locomoteur, appareil cardiorespiratoire, neurologie, pé diatrie, gé riatrie, ou divers) et du niveau (dé butant à expé rimenté ). Ré sultats : Parmi les 24 critè res de l'ERC-PT, 15 ont obtenu des taux d'observation supé rieurs à 95%. Pour ce qui est des 9 autres critè res, certains affichaient des é carts considé rables dans les taux d'observation pour le niveau, le contexte de pratique, et le domaine de pratique. La mention « avec distinction » a é té accordé e le plus souvent pour des critè res lié s au professionnalisme et à la communication, et plus souvent dans un contexte de pratique dans la collectivité qu'à l'hô pital/en é...

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