Randolph L. Berens scite author profile

The parasite Trypanosoma cruzi metabolizes allopurinol by a sequential conversion to allopurinol mononucleotide and aminopurinol mononucleotide. The latter is incorporated into RNA. This transformation of a widely used innocuous agent, allopurinol, into a toxic adenine analog appears to account for the antiprotozoan effect of allopurinol. These unique enzymatic activities appear to occur only in T. cruzi and the pathogenic lesihaminae. Allopurinol may serve as a model for the synthesis of similar antiprotozoan agents.

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Purine metabolism in the bloodstream forms of trypanosoma gambiense and Trypanosoma rhodesiense

Fish¹,

Looker²,

Marr³

et al. 1982

Biochimica et Biophysica Acta (BBA) - General Subjects

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Purine and pyrimidine salvage pathways in Leishmania donovani

LaFon

Nelson

Berens

et al. 1982

Biochemical Pharmacology

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An Easily Prepared Defined Medium for Cultivation of Leishmania donovani Promastigotes

Berens¹,

Marr²

1978

The Journal of Parasitology

103

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