A subclass of lipid flippases contribute to glycerolipid and sphingolipid homeostasis in Arabidopsis leaves, and play critical roles in cell expansion and vegetative growth. Footnotes: Author contributions: J.D. authored the manuscript. R.P. and J.D. analyzed vegetative physiology. S.M. bred the double-knockout lines and identified dwarf mutants. E.B., A.R., and J.S. performed subcellular localization experiments. L.P. and R.L. were involved in the cloning of ALA5 for yeast expression. T.B. performed lipid uptake and functional complementation assays. R.L. analyzed the data and carried out statistical analysis for yeast experiments. M.P. and R.L. supervised yeast experiments. E.C. and R.C. performed sphingolipid profiling of ala4/5 mutants. J.H. performed all plant crosses, supervised in planta experiments, and assisted J.D. in writing. J.H. agrees to serve as author responsible for contact.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.