Background: Premature rupture of membranes (PROM) is a common pregnancy complication and is associated with significant risks of fetal and neonatal morbidity and mortality. Objective: This study aimed to measure the incidence rate of preterm premature rupture of membranes (PPROM) among pregnant women attending Zagazig University Hospital, and to identify the risk factors associated with PROM and fetal/neonatal outcomes. Methods: This cross-sectional study was conducted at Zagazig University Hospitals. It included 69 women with PROM. The study was conducted from July 2019 to January 2020. All patients were subjected to detailed history taking, general examination and laboratory investigations. Results: There were 46 mother gave birth of healthy babies with good Apgar score (66.7%), 15 with babies needed O2 incubators (21.7%) and 8 with babies that were put on ventilators (11.6%). There were 68 mothers with no bad outcomes and 1 with chorioamnionitis. The risk factors of the cases showed that there were 15 with no risk factor (21.7%), 8 with previous PROM (11.6%), 6 with multi pregnancy (8.7%), 12 with antepartum (17.4%), 16 with infections (23.2%) and 12 with chronic diseases (17.4%). Conclusions: we concluded that younger, illiterate parturient women were found to be provoking factors to increased PPROM. Such hazards may affect both maternal and neonatal outcome such as infection, maternal distress, fetal distress, increase operative delivery, as well as need for neonatal intensive care unit care in more than 50% of the neonates.