The purpose of this study was to quantitatively evaluate the effects of different shades of light-polymerized resin cement on the color of two different thicknesses (0.5 mm and 0.7 mm) of three different ceramic materials (Esthetic, e.max, and ZirPress). A spectrophotometer (Color Eye 7000A -CIE (L*a*b*) was used to measure the color of specimens on the control substrate without cement, and then on (Translucent, White Opaque, B0.5, A1, and A3 of RelyX™ Veneer cement). The mean values of color difference (∆E) were higher for Esthetic, followed by ZirPress, with the lowest values for e.max. The mean values of ∆E decreased when the thickness of ceramic increased from 0.5 mm to 0.7 mm. It was observed that the White Opaque had significantly increased ∆E values when compared with (TR, B0.5, A1, and A3), whereas no significant difference between B0.5 and TR, and between B0.5 and A3.