Choosing the best bank to obtain a loan from has become a dilemma for many loan applicants; Thus the need to automate the process throughout establishing an intelligent decision support system (IDSS) to facilitate applicant's decision-making process. However, there are many types of IDSS to design the system but we have found that the fuzzy logic is more suitable. Despite the fact that Fuzzy structure has strong inference system, it has no learning ability. In the contrary, neural network (NN) has a powerful learning ability. The Adaptive Network-based Fuzzy Inference System (ANFIS) merges these two desired features in its own structure. Therefore, using the ANFIS to determine the best loan package was proven in this paper to define the suitable bank.