Acute
kidney injury (AKI) is not only a worldwide problem with
a cruel hospital mortality rate but also an independent risk factor
for chronic kidney disease and a promoting factor for its progression.
Despite supportive therapeutic measures, there is no effective treatment
for AKI. This study employs tetrahedral framework nucleic acid (tFNA)
as a vehicle and combines typhaneoside (Typ) to develop the tFNA-Typ
complex (TTC) for treating AKI. With the precise targeting ability
on mitochondria and renal tubule, increased antiapoptotic and antioxidative
effect, and promoted mitochondria and kidney function restoration,
the TTC represents a promising nanomedicine for AKI treatment. Overall,
this study has developed a dual-targeted nanoparticle with enhanced
therapeutic effects on AKI and could have critical clinical applications
in the future.
Evaluating energy savings in Chinese residential buildings (ESCRB) plays an important role in Chinese building energyefficiency work. However, the said work is currently challenged by the lack of effective method for estimating ESCRB data by summarizing all the quantifiable and unquantifiable impact factors. To overcome this problem, this study employed the equation of Human Impact, Population, Affluence, and Technology (IPAT), and the index decomposition of Logarithmic Mean Divisia Index (LMDI) to establish an effective ESCRB estimation method, and then calculated ESCRB data during the period of 2001-2015. Results of this study reflect that ESCRB has significantly accumulated with the rapid development of Chinese building energy-efficiency work in the past 15 years. In particular, ESCRB data
We propose a simple method to mitigate the cross phase modulation (XPM) effect in wavelength division multiplexing (WDM) systems, which combines the split nonlinearity compensation (NLC) and the receiver-side phase recovery algorithm. In the proposed method, the split NLC can suppress the conversion from the nonlinear phase noise (NLPN) to the Gaussian-like nonlinear interference noise (NLIN), and together with the phase recovery algorithm, which can compensate for the NLPN, the impact of the XPM on the signal is finally mitigated. This method is demonstrated by a transmission simulation with 11 WDM channels and 32 Gbaud 16 QAM modulations. The simulation results show that, due to the XPM mitigation, the proposed method can provide 0.4 dB gain for 500-km transmission, 0.3 dB gain for 2000-km transmission, and about 0.2 dB gain for 3000-km to 10000-km transmissions. The influence of the transmission distance on the gain is also discussed. Moreover, the selection of the phase recovery algorithm for different transmission distances is investigated, and the results show that for a short distance the blind phase search (BPS) is better, but for a long distance the V&V algorithm is more appropriate.
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