Computational integrative analysis has become a significant approach in the data-driven exploration of biological problems. Many integration methods for cancer subtyping have been proposed, but evaluating these methods has become a complicated problem due to the lack of gold standards. Moreover, questions of practical importance remain to be addressed regarding the impact of selecting appropriate data types and combinations on the performance of integrative studies. Here, we constructed three classes of benchmarking datasets of nine cancers in TCGA by considering all the eleven combinations of four multi-omics data types. Using these datasets, we conducted a comprehensive evaluation of ten representative integration methods for cancer subtyping in terms of accuracy measured by combining both clustering accuracy and clinical significance, robustness, and computational efficiency. We subsequently investigated the influence of different omics data on cancer subtyping and the effectiveness of their combinations. Refuting the widely held intuition that incorporating more types of omics data always produces better results, our analyses showed that there are situations where integrating more omics data negatively impacts the performance of integration methods. Our analyses also suggested several effective combinations for most cancers under our studies, which may be of particular interest to researchers in omics data analysis.
Videos contain various types and strengths of motions that may look unnaturally discontinuous in time when the recorded frame rate is low. This paper reviews the first AIM challenge on video temporal super-resolution (frame interpolation) with a focus on the proposed solutions and results. From low-frame-rate (15 fps) video sequences, the challenge participants are asked to submit higher-framerate (60 fps) video sequences by estimating temporally intermediate frames. We employ the REDS VTSR dataset derived from diverse videos captured in a hand-held camera for training and evaluation purposes. The competition had 62 registered participants, and a total of 8 teams competed in the final testing phase. The challenge winning methods achieve the state-of-the-art in video temporal superresolution. Resolution Members: Seungjun Nah 1
With the development of deep learning, research on image target recognition has made great progress in recent years. Remote sensing detection urgently requires target recognition for military, geographic, and other scientific research. This paper aims to solve the synthetic aperture radar image target recognition problem by combining deep and kernel learning. The model, which has a multilayer multiple kernel structure, is optimized layer by layer with the parameters of Support Vector Machine and a gradient descent algorithm. This new deep kernel learning method improves accuracy and achieves competitive recognition results compared with other learning methods.
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