Background: Gestational Diabetes Mellitus (GDM) refers to glucose intolerance diagnosed at onset or first recognition during pregnancy. Women with GDM are at risk for maternal and foetal complications, so it is important to screen all pregnant women. The present study was carried out to determine the significance and use of the 75 g Oral Glucose Challenge Test (OGCT) using the Diabetes in Pregnancy Study Group India (DIPSI) criteria for screening of GDM. Objectives: This study was planned to analyze the incidence of GDM in pregnant women attending antenatal care clinic, using DIPSI criteria 75 g OGCT in the first trimester or at the first antenatal visit. Methods: In this prospective observational study, 451 pregnant women attended the antenatal clinic for the first visit at gestation between 6 and 20 weeks. 75 g oral glucose is administered irrespective of whether she is in the fasting or non-fasting state, without regard to the time of the last meal and GDM was diagnosed, and treatment started. Maternal and fetal outcomes were measured. Results: The incidence of GDM using DIPSI criteria (>140 md/dL) was 20.8% in the first trimester or first antenatal visit. Incidence of maternal and foetal complications was lower in our study when compared to other studies. Conclusion: It is concluded that a 75 g glucose challenge test at 6-20 weeks of gestation with a cut-off value of 140 mg/dl is a reliable screening test for GDM. Keywords: Gestational diabetes mellitus; Oral glucose challenge test (OGCT); Glucose intolerance; DIPSI criteria
Leiomyosarcoma is a rare tumor that accounts for about 2 to 5% of uterine malignancies originating from the smooth muscles of the uterus. Women can be affected at any age group; however, the majority get diagnosed at their perimenopausal age. The early-stage diseases are managed by hysterectomy and complete surgical resection. In the present case report, we discuss a 41-year-old female with a tumor mass of approximately 32-week gestation at the time of examination. The patient had a regular menstrual cycle with no abnormal uterine bleeding except for abdominal pain for three months. A large, lobulated mass (25 x 18 x14 cm) with solid, cystic, and hemorrhagic components was removed surgically (total abdominal hysterectomy) from the uterus's fundus and spalingo-oophorectomy. The patient developed severe hypotension and tachycardia post-surgery and required a longer recovery time. We referred the patient to the medical oncologist for further treatment. In our patient, the tumor rapidly increased, and metastasis was noted in the peritoneal fluid. A further follow-up will be needed to understand the course of the disease and its outcome. Keywords: Leiomyosarcoma; Smooth muscle tumors; Uterine fibroid; Uterine myoma
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