Fetal and/or neonatal brain development, both normal and abnormal RESULTS: Multiple oxysterols were identifi ed in human maternal breast milk that induced oligodendrocyte production from NSCs in vitro. We found that Gli2 is functionally required for oxysterol-induced oligodendrogenesis. Following neonatal WMI in vivo, 20HC treatment increased numbers of mature OLs, improved myelination and rescued motor defi cits in mice. Lineage tracing experiments showed that 20HC-mediated recovery of OL defi cit is mediated in part through 20HCinduced SVZ-derived oligodendrogenesis in vivo. Additional recovery may be due to the impact of 20HC on oligodendrocyte progenitor cell maturation.
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