Since the 19th century, Argentina has been characterized as an agro-exporting country reaching its peak after the First World War. Nowadays, in addition to exporting agricultural goods, Argentina has become a producer of an increasingly valuable raw material in the business world: scientific information. The accelerated increase in the production of scientific articles in high impact international journals makes Argentinean science visible all over the world. With the present study, we intend to unveil how Argentinean scientific information serves as building blocks of patents requested by foreign companies and institutions. According to the area of knowledge analyzed, we identify a differential flow of information towards the development of technologies in industrial countries. Moreover, we detected that the blind technology transfer phenomenon is a dynamic process. Herein, we present relevant evidence of scientific information flowing towards foreign technologies within 2 years after the article publication. These results suggest the need for the development of strict technology transfer policies in Argentinean universities and academic institutions in order to protect the state investment in science. Our findings highlight scientific production as a unique opportunity for economic growth and expansion of the country. This may become a fertile ground for political and economic debate.
Cell surface glycans play essential roles in diverse physiological and pathological processes and their assessment has important implications in biomedicine and biotechnology. Here we present a rapid, versatile and single-step multicolor flow cytometry method for evaluation of cell surface glycan signatures using a panel of selected fluorochrome-conjugated lectins. This procedure allows simultaneous detection of cell surface glycans with a 10-fold reduction in the number of cells required compared to traditional multistep lectin staining methods. Interestingly, we used this one-step lectin array coupled with dimension reduction algorithms in a proof-of-concept application for discrimination among different tumor and immune cell populations. Moreover, this procedure was also able to unveil T, B and myeloid cell sub-clusters exhibiting differential glycophenotypes. Thus, we report a rapid and versatile lectin cytometry method to simultaneously detect a particular repertoire of surface glycans on living cells that can be easily implemented in different laboratories and core facilities.
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