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In this paper, a typical combined cycle power generation unit in Iran is simulated by a mathematical method in order to perform sensitivity analysis on environmental emission and electricity price. The results of this study demonstrate that the efficiency of the power plant depends on both gas turbine design parameters such as gas turbine inlet temperature, compressor pressure ratio and steam cycle design parameters such as HRSG pinch point temperature, condenser pressure. The results demonstrate that an increase in TIT and compressor pressure ratio have a significant effect on exergy efficiency and destruction.