Background: Depression is a common psychosocial problem that negatively affects the lives and relationships of school-age children, adolescents, and adults both in private and public. Purpose: To explore the psychosocial well-being among Jordanian schoolage children and adolescents who are complaining of end stage renal disease (ESRD) undergoing hemodialysis. Method and Design: The study was carried out using a descriptive crosssectional correlation design. A convenient sample of 121 school-age children and adolescent were recruited from seven major dialysis units in Jordan . The children's psychosocial well-being was measured by using a self-report questionnaire. This, however, includes demographic data, adherence to treatment, Dialysis Patient-Perceived Exercise Benefits, and Barriers Scale. Also, Pediatrics Quality of Life PedsQL 3.0 ESRD and Depression Scale for Children were used for data collection
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