Objectives: Convalescent plasma (CP) as a passive source of neutralizing antibodies and immunomodulators is a century-old therapeutic option used for the management of viral diseases. We investigated its effectiveness for the treatment of COVID-19. Design: Open-label, parallel-arm, phase II, multicentre, randomized controlled trial. Setting: Thirty-nine public and private hospitals across India. Participants: Hospitalized, moderately ill confirmed COVID-19 patients (PaO2/FiO2: 200-300 or respiratory rate > 24/min and SpO2 ≤ 93% on room air). Intervention: Participants were randomized to either control (best standard of care (BSC)) or intervention (CP + BSC) arm. Two doses of 200 mL CP was transfused 24 hours apart in the intervention arm. Main Outcome Measure: Composite of progression to severe disease (PaO2/FiO2<100) or all-cause mortality at 28 days post-enrolment. Results: Between 22 nd April to 14 th July 2020, 464 participants were enrolled; 235 and 229 in intervention and control arm, respectively. Composite primary outcome was achieved in 44 (18.7%) participants in the intervention arm and 41 (17.9%) in the control arm [aOR: 1.09; 95% CI: 0.67, 1.77]. Mortality was documented in 34 (13.6%) and 31 (14.6%) participants in intervention and control arm, respectively [aOR) 1.06 95% CI: -0.61 to 1.83]. Interpretation: CP was not associated with reduction in mortality or progression to severe COVID-19. This trial has high generalizability and approximates real-life setting of CP therapy in settings with limited laboratory capacity. A priori measurement of neutralizing antibody titres in donors and participants may further clarify the role of CP in management of COVID-19.

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In the present study the birth order and Adjustment among college students has been studied. Sample of the study has been chosen from medical and engineering college students of Jalna and Aurangabad District in Maharashtra. In each 30 first born students (15 Boys and 15 Girls students). 30 second born (15 Boys and 15 Girls students) and third born students (15 Boys and 15 Girls students) the scale was used for data collection Bell’s Adjustment Inventory by Lilit Sharma. 3×2 factorial design was used and data were Analysis by mean, SD and ANOVA. It has been found that there is no significance difference between first born, second born and third born students on Home, Social, Emotional and Health Adjustment.

The study was undertaken to study the psychological well being of male and female college students of district Jalna (M.S.). The sample of the study Consisted 100 college students (50 male students and 50 female students). Randomly secreted from Difference College of Jalna District. Devendra Singh Sisodia and Pooja Choudhary by psychological wellbeing scale was used data collection. The data collected was statistically treated by using mean, SD and one way ANOVA. The findings of the study revealed that there is significant difference between male and female college students on psychological well-being. Furthermore the results highlight that female student has high psychological well-being, efficiency, mental health and interpersonal relations as compared to male students. Male students have high satisfaction and sociability than female college students.

Mental Health is “the emotional and spiritual resilience which enables us to enjoy life and survive pain, suffering and disappointment. It is a positive sense of well being and an underlying belief in our and others dignity and worth. It is influenced by our experience and our genetic inheritance.” The purpose research attempted to study the gender difference between mental health. To study by research seared variables in gender and mental health sub factor. A sample of 100 participants 50 Male (25 Urban and 25 Rural) & 50 Female (25 Urban and 25 Rural)) was drawn randomly from the population. Mental health inventory developed by Dr. Jagdish & Dr. A.K. Srivastava (1983) was used for data collection. Factorial design was used and data were analysis by Mean, SD and ‘F’ values. Results show that 1) Male College Students high Positive self Evaluation than Female College Students. 2) There is no significant difference between Male and Female College on Perception of Reality. 3) Male College Students high Integration of Personality than Female College Students. 4) There is a not significant difference between Male and Female College on Autonomy. 5) There is not significant differences between Male and Female college students on Group Oriented Attitudes. 6) Female College Students high Environment Mastery than Male College Students.7) There is a not significant difference between Male and Female College students on Mental Health.