BACKGROUND Stroke is the leading cause of disability worldwide, the second most common cause of dementia and the third leading cause of death. It is unclear whether serum uric acid promotes or protects against the cerebrovascular disease. Hence, a search for other risk factors is the need of the hour. The aim of the study is to study the role of serum uric acid, serum calcium and serum albumin in acute ischaemic stroke and its effect on stroke outcome. MATERIALS AND METHODS A cross-sectional study was carried out in ESIC Medical College and PGIMSR, Rajajinagar, Bengaluru, over a period of 18 months in 100 cases of who met the inclusion criteria were studied. Patients presenting within 72 hours of onset and aged ≥40 years were included in this study. Apart from routine investigations, serum albumin, calcium and uric acid levels were done in all patients. RESULTS Out of 100 patients, 63% were males and 37% were females. Ratio was 1.7:1. Majority of stroke population are between 50 to 69 years. Hypertension constitutes the major risk factor in this population as 79% of population is hypertensive. Serum calcium, albumin and uric acid values had a highly significant correlation with neurological severity by NIHSS scores (p<0.001) and with the short-term outcome by Barthel index (p<0.001). CONCLUSION Serum albumin, serum calcium and serum uric acid values can predict initial neurologic severity and short-term outcome in AIS.
BACKGROUNDChronic and excessive alcohol ingestion is one of the major causes of liver disease. The traditional disease specific prognostic model used for this purpose is the Maddrey Discriminant Function (DF). MELD score has been recently developed to predict mortality in patients with alcoholic hepatitis.This study aims at correlating MELD score, serum sodium, MELD NA score, serum albumin and Maddrey discriminant function in determining short-term prognosis in patients with alcoholic liver disease and its complications. MATERIALS AND METHODSA total number of 100 patients of age >18 years with significant history of alcohol abuse who were admitted in ESIC, PGIMSR, Bengaluru, with alcoholic liver disease or related complications who met the inclusion and exclusion criteria were analysed. MELD, DF, MELD NA were calculated at admission and correlated with severity and mortality. RESULTSThere were 16 deaths in the study attributable to alcoholic hepatitis or its complications. We found that DF largely correlates with MELD at lower values; at higher values, many patients have disproportionally higher MELD score compared to DF. Among these patients, deaths appear to track more closely with MELD rather than DF. CONCLUSIONIn summary, MELD and MELD NA are useful for predicting 30-day mortality in patients with alcoholic hepatitis and maintains some practical and statistical advantages over DF in predicting mortality rate in these patients. The MELD NA score performed better than MELD in predicting short-term mortality. Presence of ascites, hyponatraemia, hepatic encephalopathy, variceal bleeding and SBP were independent predictors of adverse prognosis in alcoholic hepatitis/cirrhosis. KEYWORDSALD, MELD, DF, MELD NA, Hyponatraemia, ROC and AUROC.HOW TO CITE THIS ARTICLE: Nalapur VT, Basavaiah R. A clinical study of spectrum of alcoholic liver diseases with respect to predictors of severity and prognosis. J. Evid. Based Med.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.