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One of the problems that often arise during the application of medical research to real life is the high number of false positive cases. This situation causes experts to be warned with false alarms unnecessarily and increases their workload. This study proposes a new data centric approach to reduce bias-based false positive predictions in brain MRI-specific medical object detection applications. The proposed method has been tested using two different datasets: Gazi Brains 2020 and BraTS 2020, and three different deep learning-based object detection models: Mask R-CNN, YOLOv5, and EfficientDet. According to the results, the proposed pipeline outperformed the classical pipeline, up to 18% on the Gazi Brains 2020 dataset, and up to 24% on the BraTS 2020 dataset for mean specificity value without much change in sensitivity metric. It means that the proposed pipeline reduces false positive rates due to bias in real-life applications and it can help to reduce the workload of experts.

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Periodic spatio-temporal co-occurrence patterns (PECOPs) represent subsets of object-types that are often periodically located together in space and time. Discovering PECOPs is an important problem with many applications such as discovering interactions between animals and identifying tactics in games. However, mining PECOPs is computationally very expensive because the interest measures are computationally complex, databases are larger due to the archival history, and the set of candidate patterns is exponential in the number of objecttypes. In this paper, we define the problem of mining PECOPs, and propose a novel PECOP mining algorithm. The experimental results show that the proposed algorithm is computationally more efficient than the naïve alternatives. Keywords-spatio-temporal periodic co-occurrence pattern mining spatio-temporal data mining, spatial co-location, dynamic time warpingI.

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