Although tremendous progress has been made in conventional treatment for ischemic heart disease, it still remains a major cause of death and disability. Cell-based therapeutics holds an exciting frontier of research for complete cardiac recuperation. The capacity of diverse stem and progenitor cells to stimulate cardiac renewal has been analysed, with promising results in both pre-clinical and clinical trials. Mesenchymal stem cells have been ascertained to have regenerative ability via a variety of mechanisms, including differentiation from the mesoderm lineage, immunomodulatory properties, and paracrine effects. Also, their availability, maintenance, and ability to replenish endogenous stem cell niches have rendered them suitable for front-line research. This review schemes to outline the use of mesenchymal stem cell therapeutics for ischemic heart disease, their characteristics, the potent mechanisms of mesenchymal stem cell-based heart regeneration, and highlight preclinical data. Additionally, we discuss the results of the clinical trials to date as well as ongoing clinical trials on ischemic heart disease.
Introduction:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease-2019 (COVID-19) outbreak became a pandemic across the world after the outbreak in China in December 2019. This study aimed to determine the impact on the emergency orthopedic fixation during the COVID-19 pandemic in the Institute of Orthopaedics and Traumatology, Coimbatore. Materials and methods: This is a retrospective study done on patients of trauma admitted in the emergency orthopaedic unit, under Tamilnadu Accident and Emergency Care Initiative (TAEI), Coimbatore Medical College Hospital from April 2020 to December 2020. All the patients admitted were evaluated as per the routine protocols followed in this COVID-19 pandemic in our institution and the patients were taken up for emergency orthopedic fixation based on the COVID-19 status. Results: The total number of emergency orthopedic surgical fixation procedures done during the pandemic period from April 2020 to December 2020 was 245. Orthopedic surgical fixation done in elective theatres during this pandemic in 2020 is 245 cases. As per the results, during the COVID-19 pandemic, emergency orthopedic surgical fixation was not stopped and treated as per the COVID-19 protocol followed in our hospital. Conclusion:The SARS-CoV-2 (COVID-19) pandemic has a major impact on orthopedic surgical fixation. All the patients admitted should be evaluated for the COVID-19 infection and use of adequate personal protective equipment while treating the patients to deliver safe and effective surgical services during this COVID-19 pandemic.
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