Background:Cancer is a disease that evokes wide spread fear among people and is one of the leading causes of deaths in the world. Diethylnitrosamine (DEN) is a known carcinogen in rodent liver. DENs reported to undergo metabolic activation by cytochrome P450 enzymes to form reactive electrophiles that cause oxidative stress leading to cytotoxicity, mutagenicity and carcinogenicity.Objective:The present study was carried out to evaluate the antioxidant activity of ethanolic extract of Tinospora cordifolia (EETC) in N-nitrosodiethylamine (DEN) induced liver cancer in male Wister albino rats.Materials and Methods:The antioxidant activity was assessed by the levels of lipid peroxidation (LPO), enzymic and nonenzymic antioxidants.Result:A significant levels of LPO was increased as the enzymic and nonenzymic antioxidants values were decreased in liver cancer bearing animals.Conclusions:The administration of EETC to cancer bearing animals reverted the LPO levels, enzymic and nonenzymic antioxidants to near normal
The goal of this study is to look into the preliminary phytochemical and GC-MS analyses of a methanol extract of the leaves of Acalypha indica. Alkaloids, tannins, steroids, saponins, flavonoids, glycosides, and phenolic substances are found in leaf extract after phytochemical analysis. A. indica is a plant that grows in the southern Indian state of Tamil Nadu. It has medicinal characteristics and is used as a diuretic, anthelmintic, and respiratory disorders like bronchitis, asthma, and pneumonia. The present work is designed to investigate GC-MS. Thirty compounds are found in the leaf extract. The structure-based biological activities study supported the Pass online database findings from the current study support that the use of this plant compound responsible for the anticancer activity is based on structure-based drug development. Based on in-silico results, it was shown that the interactions of hydrogen bonds, binding affinity with JAK2 kinase inhibitors, tumor suppressor proteins pRB Retinoblastoma protein, and COX-2 target proteins were compared with known values. It can be considered an increase in the possibility of conniving potential anticancer drugs as an anti-inflammatory agent.
Farm mechanization is the main indicator of modernizing the agriculture and use of farm machines that can take the place of human and animal power in agricultural processes. During field operation the weight of farm machinery compact the agricultural soil due to the contact with the tires or tracks of tractors. The aim of the article is to study the effects of soil texture and moisture content on soil compaction. During field experimental test 5 different depth (5, 10, 15, 20 and 25 cm) were selected for taking soil compaction data and soil samples at three depth range (0-10, 10-20 and 20-30 cm) from Kulumsa Agricultural research center farm land at two seasons. During compaction test 15 sample point data were taken from 0.6 ha farm land. The result of the study shows from average of all sample point the maximum and minimum value of soil compaction value where 3.73 Mpa and 3.032 Mpa during harvesting season and 1.37 Mpa and 1.19 Mpa during seeding season respectively. The laboratory result shows farm land soil is clay with 25.0% of sand, 51% of clay and 24 % silt during both experimental seasons. The maximum and minimum percentage of soil moisture value where 28.92% and 20.04% during harvesting season and 41.8% and 30.8% at 20 to 30 cm and 0 to 10 cm depth respectively.
The scarcity of petroleum products is forcing renewable energy resources to be more attractive. Biodiesel is an alternative fuel created through the transesterification of vegetable oils and animal fats. The most important biodiesel quality parameters are obtained by paying attention to and making a trade-off between reaction time and temperature. The presence of contaminants in the feedstock, such as water and free fatty acids, or impurities in the final products, such as methanol, free glycerine, or soap, causes difficulties during this process. This research work has developed processes to produce biodiesel from Jatropha curcas. The biodiesel was extracted and all the blends were characterized to determine the physicochemical characteristics by the test methods ASTM 6571. The emission characteristics indicate that B20 was less than all types of oil samples. The power and torque outputs of B20 were found better than all blends next to the baseline diesel fuel. The smell of the smoke of B40 was spicy and its smoke density was very little as compared to all types of fuel samples. The novel finding of this study was that increasing the biodiesel in the blend increases brake power, and torque and reduces brake-specific fuel consumption.
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