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Background: A strong association between abnormal lipid variables and development of atherosclerosis is widely established. However, few data exist on the association between lipid levels and the extent or severity of coronary lesions in patients with coronary artery disease. Objective: We aimed to determine the link between lipid levels and the extent or severity of coronary lesions in patients with suspected coronary artery disease using Friesinger index (FR). Methodology: In this prospective and singe-center study, consecutive patients who underwent coronary angiography for diagnostic purposes were analyzed. Each participant was evaluated for lipid levels i.e. total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol, non-HDL cholesterol, triglycerides/ HDL cholesterol, and triglycerides/non-HDL cholesterol. The extent of coronary disease was evaluated using FR index. Results: A total of 566 patients (mean age: 56.17 ± 9.99 years) were included in the study. The mean FR index was 5.40 ± 3.78. A significantly positive correlation was observed between FR index and total cholesterol (P = 0.002), triglycerides (P < 0.001), VLDL cholesterol (P < 0.001), non-HDL cholesterol (P = 0.006), triglycerides/HDL cholesterol ratio (P = 0.008), and triglycerides/non-HDL cholesterol ratio (P = 0.002). On the contrary, an inverse correlation was observed between FR index and HDL cholesterol (P < 0.001). Age or gender played no role in governing the FR index severity, while body-mass index, hypertension, diabetes, and smoking showed significant association with FR index (P < 0.001 for all). Conclusion: The present study demonstrates a significant link between the extent of coronary artery disease and levels of certain lipid variables.

Conclusion Chemiluminescent SARS-CoV-2 IgG assay can be used as a semiquantitative test, with a cut-off of >8Á19S/Co ratio for selecting donors for convalescent plasma therapy and assessing efficacy of vaccination.

Background Severe acute respiratory syndrome corona virus 2(SARS-CoV-2), the causative agent of corona virus disease-2019(COVID- 19) which has led to a global pandemic. The true extent of the burden of COVID-19 may be underestimated, and there is need to know the current prevalence of SARS-CoV-2 antibody in population. Methods The present study was a cross-sectional study to assess prevalence of SARS-CoV- 2 IgG antibody among 586 healthy voluntary blood donors who donated whole blood between mid-December 2020 to January 2021. A chemiluminescence assay was used to detect the presence of SARS-CoV-2 IgG antibody in serum samples in addition to recommended transfusion transmitted infections tests and Signal to Cut Off (S/C) > 1 was considered as reactive for antibody as per manufacturer’s instructions. Results In the present study, 586 healthy voluntary blood donors were enrolled and were screened for SARS- CoV-2 IgG antibody. Out of 586 donors, 52 donors had indeterminate values of SARS-CoV-2 IgG antibody. A total of 534 healthy voluntary blood donors’ samples were included in the present study for analysis. Out of total 534 healthy blood donors, 42.88% (229) were found to be seropositive while 57.11% (305) were found to be seronegative. Conclusion A 43% positivity of SARS-CoV-2 IgG antibody among healthy blood donors was detected which is an indication of presence of infection at community level and majority of the population already has been exposed to SARS-CoV-2 infection. However, there was no statistically significant association of type of blood group and age with seropositivity.

Peripheral smears of the cases having inconsistent eosinophilia result with that of Sysmex XS-800i analyzer should be examined carefully for the presence of malaria parasites in the red blood cells. Sysmex XS-800i analyzers have moderate range of sensitivity and high degree of specificity in diagnosing malaria as spurious eosinophilia.

HLA‐A*01:01:01:92 differs from HLA‐A*01:01:01:01 by a single nucleotide G‐>C change at gDNA‐56 position.

Sickle cell disease is an inherited blood disorder that affects red blood cells. It is characterized by polymerization of haemoglobin, erythrocyte stiffening, and subsequent vaso-occlusions. These can lead to microcirculation obstructions, tissue ischemia, infarction and acute stroke. Transient ischemic attack, Ischaemic stroke, haemorrhagic stroke, silent cerebral infarction, headache, Moyamoya disease, neuropathic pain, and neurocognitive impairment are neurological complications of sickle cell disease. Here we report a case of ischemic stroke in a patient of sickle cell disease. For early diagnosis and proper management of sickle cell disease neurological complications require specialised haematological and neurological expertise. The newly used medications under ongoing research will be the hope to overcome this devastating disease and its complications.

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