Although healthy older adults show the normal amygdala-modulated criterion shift for emotional items-influencing their subjective feeling that information has been previously encountered, the amygdala pathology present in early AD may disrupt this influence.

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The authors investigated gist memory (the general meaning, idea, or gist conveyed by a collection of items) for categorized color photographs in patients with Alzheimer's disease (AD) using an experimental paradigm in which participants are instructed to respond "yes" when a test item fits with a previously studied category, regardless of whether the specific item was actually studied. Compared with controls, the patients endorsed fewer studied items and similar numbers of nonstudied lure items. After the authors corrected for the baseline false-alarm rate, the patients showed a lower level of endorsements for nonstudied lure items compared with that of controls, suggesting that their gist memory is impaired. Implications of these findings for understanding gist memory and response bias in patients with AD are discussed.

No abstract