One-hundred-and-thirty-six children below 12 years of age hospitalized with a diagnosis of tuberculous meningitis (TBM) have been investigated to identify the underlying cause of convulsions. One-hundred-and-one children (74 per cent) presented with seizures before and/or during hospitalization. Generalized tonic and clonic seizures (GTCS) were the commonest (58 per cent) type of seizures followed by focal seizures (FS) (38 per cent) and tonic spasms (TS) (4 per cent). EEG changes were more frequently observed in cases with FS and in those children with GTCS who presented after first week of hospitalization. EEG findings included generalized dysrythmia with paroxysmal slow activity (38 per cent), interhemispheric asymmetry (23 per cent), multiple spike and wave pattern (10 per cent), and focal spike and wave pattern (15 per cent). CT scan findings were more common in those children with GTCS and TS who presented with recurrent seizures and/or seizures manifesting after first week of hospitalization. FS presenting at any stage of the disease were associated with CT scan abnormalities. Abnormalities detected in CT scan of brain included meningeal enhancement (55 per cent), hydrocephalus (32 per cent), tuberculomas (27 per cent), and cerebral infarctions (13 per cent). Clinical presentation and investigations indicate that the probable cause of convulsions could be attributed to cerebral edema (57 per cent), syndrome of inappropriate secretion of antidiuretic hormone (35 per cent), hydrocephalus (32 per cent), tuberculoma (27 per cent), abnormal electric focus (25 per cent), and cerebral infarction (13 per cent).
During episodes of severe thrombocytopenia, most children have clinically mild disease. When the PC is < 10,000/microl clinically mild disease is observed less often compared to episodes with PC 10,000-20,000/microl. Based on these observations, it can be recommended that during severe thrombocytopenia, particularly when the PC is between 10,000-20,22,000/microl, patients can be safely managed with watchful waiting without any specific therapeutic intervention.
We conclude that antithymocyte globulin and cyclosporin combination is an effective treatment for aplastic anemia patients who are ineligible for bone marrow transplantation.
In the projects Smartblades and Smartblades 2 a full-scale 20 m rotor blade for the NREL CART3 wind turbine was designed, built and tested. The rotor blade was intended to have a strong bending–torsion coupling. By means of the experiments, the proof for the technology in question was supposed to be provided. The experimental work was accompanied by simulations. The aim of the paper was to describe and publish a reference finite element model for the 20 m rotor blade. The validation procedure is presented, as are the modelling strategy and the limitations of the model. The finite element model is created using quadratic finite shell elements and quadratic solid elements. Different data sets were used for the validation. First, the data of static test bench experiments were used. The validation comprised the comparison of global displacement and local strain measurements for various flap and edge bending tests and for torsion unit loading tests. Second, the blades’ eigenfrequencies and eigenvectors in clamped and free–free scenarios were used for validation. Third, the mass distributions of the finite element and real blade were investigated. The paper provides the evaluated experimental data, and all analysed scenarios and the corresponding finite element models in Abaqus, Ansys and Nastran and formats as a reference dataset.
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