HighlightsPentavalent reassortant rotavirus vaccine was tested for efficacy in infants.The vaccine (BRV-PV) showed excellent tolerability and a good safety profile.Primary analysis efficacy was 36% against SRVGE and up to 60.5% against VSRVGE.The efficacy through 2 years of age was 39.5% (SRVGE) and 54.7% (VSRVGE).The intent to treat analyses confirmed all the per protocol analyses.

PurposeCorrect positioning and alignment of the prosthesis is a very important factor for durability of prosthesis and implant survival which is improved with the use of technology in total knee arthroplasty. However, the long‐term functional outcomes and survivorship are unclear. For this study, it was hypothesized that mechanical axis alignment of lower limb, post‐operative joint line restoration, femoral and tibial component alignment is more accurate with the new handheld semi‐active robotic‐assisted TKA. MethodFrom April‐2019 to March‐2020, 60 patients with unilateral knee osteoarthritis who underwent total knee arthroplasties were included in this prospective randomised controlled study. Computer generated randomization was used. Study included 48 female patients and 12 male patients. Pre‐operative and post‐operative radiographic measurements were done and compared between the two groups. ResultsThere was a significant difference between two groups with respect to mechanical axis deviation, joint line deviation and coronal alignment of femoral and tibial prosthesis. Mechanical axis deviation > 3° was seen in eight cases (28.5%) in C‐TKA group compared to one case (3.1%) in RA‐TKA (p 0.019). Joint line deviation of 3.5 mm was noted in C‐TKA group as compared to 0.9 mm in RA‐TKA group (p < 0.001) which was statistically significant. However, whether this difference of 2.6 mm of joint line elevation between C‐TKA and RA‐TKA leads to any difference in clinical outcome in terms of knee kinematics and knee flexion needs to be investigated with further studies. Clinically restoring normal joint line is important for improved knee function after primary TKA. No significant difference was noted in femoral component rotation on post‐operative computed tomography (CT) scan. ConclusionThe novel imageless, handheld semi‐autonomous robotic system for TKA is highly accurate with respect to component positioning in coronal plane and mechanical alignment as compared to conventional TKA. Joint line is elevated in conventional TKA but is accurately restored using the robotic‐assisted TKA which may lead to better patellofemoral kinematics. Level of evidenceI.

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