A new method for one-pot synthesis of 2,3-substituted piperidine from N-PMP aldimine and aqueous glutaraldehyde via formal [4+2] cycloaddition is reported. This reaction involves organocatalytic direct Mannich reaction-reductive cyclization with high yields (up to 90%) and excellent enantioselectivities (up to >99%). The practicability of this method is also shown at a gram scale as well as through the synthesis of functionalized (-)-anabasine.
A new class of thiazole based organogelator was synthesized and characterized by various techniques such as VT-NMR, IR, single crystal and powder X-ray diffraction. The role of unusual H-bond interactions such as C-H … N and van der Waals interactions were probed as driving forces for physical gelation of various polar and non-polar solvents. A structure-property correlation between various derivatives of thiazole was explored for their gelation or non-gelation behaviour.
A new method for asymmetric synthesis of 2,3-substituted pyrrolidines from N-PMP aldimines and succinaldehyde via formal [3+2] cycloaddition is reported. This reaction involves proline catalyzed direct Mannich reaction and acid catalyzed reductive cyclization with high yields (up to 78%) and excellent enantioselectivities (up to >99%).
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