The current study to formulate, evaluate and optimize carbimazole immediate release tablet by using quality by design approach. The look at of optimization formula and experimental design had been done with the aid of using design parameter primarily based totally on Box-Behnken design. Immediate release dosage form for rapid efficacy and inhibit the peroxidase enzymes and act as thyroid inhibitor. Method: Immediate release carbimazole tablets were manufactured by dry granulation using Quality by Design. The optimization of the formulation of tablets is done by examining the profile of the objective quality product. Microcrystalline cellulose, anhydrous lactose and magnesium stearate were all included in experiments designed using the Box-Behnken design. Their concentrations are influenced by the drug disintegration and release factor f2. Result: Optimized batch formulation shows immediate drug release with short disintegration time. In anova models are significant. Conclusion: The utilization of bound together quality by design approach for successful advancement of an IR carbimazole tablet. The effective tablet created with Box-Behnken designs.
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