No abstract

We report the case of a 67-year-old woman who presented with a persisting corneal erosion after blunt injury. Six years later, a highly prominent corneal tumor had developed at the site of the initial erosion. Histological analysis revealed a malignant melanoma. This case provides evidence that malignant melanoma may be a long-term complication of corneal epithelial disorders.

material is associated with abnormal metabolism of glycosaminoglycans and thus abnormalities of the basement membrane in the epithelial cells. Pseudoexfoliation syndrome occurs in all areas of the world with varying frequency. There is a high prevalence of pseudoexfoliation syndrome in Scandinavian countries, Arabic populations and in Oman [6,7] whilst it is relatively rare among African Americans, Eskimos and Canadian Arctic populations. Pseudoexfoliation syndrome is more common in females than in males [8] and its prevalence increases steadily with age and is rarely seen before the age of 50. Jonasson et al. reported a 10% annual increase for both open-angle glaucoma and pseudoexfoliation in persons of 50 years and over in Iceland 9]. The reported mean age ranges from 69-75 years. Genetic factors influencing pseudoexfoliation has been explored considerably in the latest decade [10]. Recent genetic studies in multiple populations have identified the lysyl oxidase-like 1 (LOXL1) gene as a major contributor to the risk of developing pseudoexfoliation syndrome and pseudoexfoliation glaucoma. LOXL1 belongs to the lysyl oxidase family of extracellular enzymes that have multiple functions including the synthesis and maintenance of elastic fibres. However, the exact relationship between LOXL1 polymorphisms and the development of pseudoexfoliation has not been completely elucidated and thus the value of genetic testing for this disorder for the time being has not been validated [11]. In addition to heritable a number of nongenetic factors such as ultraviolet light, autoimmunity, slow virus infection, and trauma are supposed to have an implication in the development of pseudoexfoliation. It is possible that a combination of genetic and nongenetic factors may be involved

Both IOLs had comparable PCO and Nd:YAG rates three years postoperatively.