Meta-analyses demonstrated no statistically significant difference, but there were marginally fewer complications with pooled ACDs compared with manual compression (odds ratio [OR] 0.87, 95% confidence interval [CI] 0.52-1.48, p = 0.13). The Angioseal group compared with the manual-compression group (total complication rate: OR 0.84, 95% CI 0.53-1.34, p = 0.49) and the Perclose group compared with the manual-compression group (total complication rate: OR 1.29, 95% CI 0.19-8.96, p = 0.01) each demonstrated trends for and against the specified ACD, respectively. Adequately powered randomised controlled trials are required to further elucidate the efficacy of ACDs.

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