Background & Objectives: Ectopic deciduosis refers to an abnormal occurrence of decidual tissue beyond the endometrium, predominantly on the surface of the uterus, fallopian tubes, ovaries and omentum. Diffuse omental and perito-neal involvement is a perplexing manifestation that may mimic peritoneal carcinomatosis. It is not accompanied by any symptoms and complications in most of the cases and does not require treatment. However, rarely it can present with acute abdomen or imitate peritoneal malignancy and, thus, associated with diagnostic difficulties and unnecessary interventions. Aim of this case report is to describe a rare case of peritoneal deciduosis in a young female, found incidentally, during a caesarean section, mimicking metastatic nodules. Afutile hysterec-tomy along with omentectomy was performed. Methods: A case of diffuse ectopic deciduosis mimicking as peritoneal carcinomatosis in a 29 years young female with full term pregnancy was found during a lower segment caesarian section, undertaken in a tertiary care teaching hospital of Lahore, Pakistan. The histopathological diagnosis was based on common technique of paraffin embedding and hematoxylin-eosin staining along with ancillary immune-histochemical evaluation. Results: Histopathological evaluation showed ectopic decidual tissue consisted of solid nests and loosely cohesive aggregates; large polygonal cells with abundant granular eosinophilic cytoplasm; sharply defined cell borders, bland nuclei with dispersed chromatin and single conspicuous nucleoli on the surface of uterus and in omental fat. Weak staining for CD30 was observed in the decidual cell cytoplasm and negative staining for CK and Calretinin in decidual cells was found. Calretinin and CK highlight benign mesothelial cells and help to rule out differentials of mesothelioma and metastatic carcinoma. Conclusion: Peritoneal deciduosis represents a rare entity and it is important to consider this condition in patients, especially in pregnant women, to prevent unnecessary intervention In addition, distinguishing this condition from malignant neoplasms will help in deciding correct treatment options.
Objective: To determine the frequency of left ventricular failure after Non-ST elevation myocardial Infarction. Patients and Methods: This was a cross sectional study that was conducted in Cardiology department, Gulab Devi Hospital, Lahore.100 Patients presented in medical O.P.D of either gender with pre diagnosed NSTEMI (as per operational definition), NSTEMI confirmed clinically and by laboratory investigations were selected for study. Thorough history and written consent regarding study was signed by patients as well as the attendants. All the patients of LVF were labeled as per operational definition. Results: Out of 100 patients, 25 were in age group of 30-40 years whereas 75 were in age group of 41-54 years, mean age was calculated 44.06±5.63 years. There were 77% male whereas 23% of the subjects were females. Frequency of left ventricular failure was 37% after Non-ST elevation myocardial infarction. Conclusion: In this new study, we found that 37% of patients went into left ventricular failure after Non ST elevation Myocardial Infarction. The major associations of left ventricular failure were age, gender, BMI, hypertension, diabetes mellitus, smoking and dyslipidemia. Keywords: Non-ST Elevation Myocardial Infarction, Heart Failure
Objective: To evaluate the various morphologic patterns of urothelial carcinoma in transurethral resection specimen of urinary bladder. Method: One hundred ninty three biopsies of transurethral resection of bladder from different age groups without exception of sex and race were included in this study from year 2013-2019 in Services Hospital Lahore. Result: Eighty-eight cases from 193 biopsies from services hospital Lahore in 2013 to 2019 were reported as high-grade urothelial carcinoma. While 52out of 193 cases were diagnosed as nested variant of urothelial carcinoma.03 cases neuroendocrine differentiation of urothelial carcinoma is identified and 21 cases having squamous and 12 cases with sarcomatoid differentiation of urothelial carcinoma is reported. Conclusion: Urothelial carcinoma has many histological variants each having different prognosis and clinical implications. So accurate subtyping of the tumor is important for patient's better management. Key Words: Urothelial carcinoma, sarcomatoid, divergent differentiation How to Cite: Kareem H, Jahan A, Nadeem I, Sameen S, Liaqat R, Liaquat T. Various histomorphologic patterns of urothelial carcinoma in TURBT specimen. Esculapio.2020;16(04):66-69.
Background and Objective: Plateletpheresis is a process by which platelets are extracted from the donor. Donor selection is critical since donors are the sole supply of blood available to satisfy demand. The goal of this study is to investigate the causes behind plateletpheresis donor deferral in order to ensure safe blood donation. Materials and Methods: The research was carried out at the department of Haematology and Transfusion Medicine University of Child Health Sciences, The Children Hospital Lahore. 50 plateletpheresis donors who voluntarily came for donation were considered for the procedure as per guidelines and departmental standard operating procedure. The details of the procedure of plateletpheresis were explained to each donor. Donor questionnaire was filled including brief history, general physical examination, Haematological parameters such as haemoglobin and the donor blood screening was done to be considered fit for procedure. The reasons for deferral of donors were noted after all work up was done. Informed consent was taken before the procedure. Plateletpheresis was done using COM.TEC Cell Separator instrument. Results: In this study 50 donors were included. Out of 50 donors 34 were approved for procedure and 16 were deferred due to different temporary and permanent reasons. The age of the donors were in between 18 to 50 years. Major reason for temporary deferral was poor venous access (n=7, 14%) followed by the low haemoglobin value (n=4, 8%). Other reasons for temporary deferral were history of medication (n=3, 6%), low platelet count (n=4,8%), history of blood transfusion (n=1, 2%), history of vaccination n=2, 4%), leucocytosis (n=1, 2%), underweight (n=4, 8%), fever (n=1, 2%), refusal after questionnaire (n=1, 2%), seropositive for malaria and VDRL (n=3, 6%), high blood pressure (n=1, 2%), and anxiety (n=1, 2%). Permanent reasons for deferral were seropositive for HbsAg (n=2, 4%), seropositive for HCV (n=4, 8%) and tattoo (n=1, 2%). Conclusion: This study found a pattern of donor deferral in single donor platelet apheresis that was our experience in single centre. In conclusion during the selection of donors, Transfusion services should be very careful related to donor safety measures and these causes of deferral should be kept in mind.
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