<p class="abstract"><strong>Background:</strong> Tinea cruris is a common superficial dermatophytic infection of the skin occurring in 20-25% population worldwide. The various types of antifungal agents are available for topical use in treatment of tinea cruris. Clotrimazole is conventional imidazole antifungal drug whereas sertaconazole is newer imidazole antifungal claimed to be superior to clotrimazole in tinea infection. The aim of the study was to determine and compare the efficacy of potent topical azole agents 1% clotrimazole and 2% sertaconazole in patients diagnosed with tinea cruris attending out-patient department of skin and VD of tertiary care hospital in Vadodara.</p><p class="abstract"><strong>Methods:</strong> A total of 71 patients diagnosed with tinea cruris were divided into two groups. Group A received topical clotrimazole (1% cream), and Group B received topical sertaconazole (2% cream). Outcome parameters such as erythema, scaling, itching, margins of lesions and size of lesions were noted atthe time of hospital visit, by 3rd week and by 6th week for the assessment of efficacy. The statistical test used was independent student t-test and software used was SPSS 20.0.<strong></strong></p><p class="abstract"><strong>Results:</strong> At the end of follow-up phase, both the drugs were found to be effective with no recurrence or relapse of tinea cruris. However, compared to clotrimazole 1% cream, sertaconazole 2% cream had statistically significant rapid relief in terms of reduction in clinical parameters such as erythema (p&lt;0.001), scaling (p&lt;0.001), itching (p&lt;0.001), size of lesion (p&lt;0.001) and margin of lesion (p&lt;0.011).</p><p class="abstract"><strong>Conclusions:</strong> Topical sertaconazole 2% cream was found to be highly efficacious and superior to clotrimazole 1% cream in improvement of clinical parameters of tinea cruris.</p>

Background: Nowadays, brand-name drugs are becoming an out-of-pocket expense which comprises 80% of total health-care expenditures. However, generic drugs are less expensive than brand-name drugs with the same therapeutic effect, but many doctors hold negative views of generics and resist prescribing. This study was designed to assess the knowledge, attitude, and practice of doctors toward generic medicines. Methods: This was a questionnaire-based cross-sectional study conducted in a multispecialty private hospital. The study participants were doctors who were practising in a hospital during the study period (January 2017 to July 2017). The questionnaire comprises 35 questions related to demographics, knowledge, attitude, and practice evaluation of generic medicines. Descriptive statistics was applied to represent participant characteristics and response rates. Results: A total of 86 questionnaires were distributed to the doctors and the response rate was 37%. The majority of doctors who participated in this survey perceived that generic medicine is effective, safe, and has same active component, dose, and bioequivalent as the brand medicines. Majority of the doctors (72%) believe that generic drugs were manufactured by poor techniques. However, more than three-quarter of doctors (78%) routinely prescribed generic drugs. Conclusion: Most of the doctors had an honest angle about the efficacy and safety of generic medicine. However, a high proportion of physicians believe that the generic drugs are of poorer quality. To have a better understanding of the generic drug, the doctor must be well informed about the generics products during their academic career that will significantly impact health-care budgets.

Globally cancer is one of the most prevalent life-threatening diseases that have a significant impact on humans. The uncontrolled division of cells is a sign of the disease. Modern cancer therapies have several side effects on healthy cells. The problem of increasing tumour resistance to existing drug treatments is a serious concern. As a result, there is a critical need for more effective medicine to combat this condition. New ways to avoid this illness are in high need. Humans' pursuit of health is a never-ending drive for a healthier, longer life. Despite this, sickness and pain are still a part of his battle for survival. Natural products have a significant role in the battle against cancer and can be used to test novel therapeutic agents. Plants are natural remedies for a variety of illnesses. It is important to identify a variety of therapeutic plants which are useful for human being. Herbal therapies are a viable alternative to conventional cancer treatments. This article looks at plants from the Asteraceae family that have anticancer properties. Plants of the Asteraceae family play an important role in combating malignancies of the stomach, breast, colon, and lung, according to a thorough examination of research papers. The results of the study indicated a spectacular outcome in the prevention of cancer.