A forced degradation study on drug moexipril has been conducted to provide an insight into degradation products and degradation pathways as per International Conference on harmonization (ICH) Q1A (R2) guideline. Moexipril was subjected to stress conditions by hydrolysis (acidic, alkaline and neutral), oxidation, photolysis and thermal. The drug degraded in the stress conditions of hydrolysis, oxidation and photolysis but remained stable in conditions of thermal stress. A total of 5 degradation products were formed from the drug, which were separated by developed gradient liquid chromatographic method on a C-18 column (4.6 × 150 mm, 5 μm) by gradient elution technique using ammonium acetate buffer and methanol at mobile phase flow rate of 1.0 mL/min at 25°C. The degradation products were identified and structurally elucidated by using liquid chromatography with quadrupole time of flight electrospray ionization tandem mass spectrometer combined accurate mass measurements. The most probable structures for the observed degradation products were assigned by comparing the product ions of all the protonated degradation products with the product ions of protonated moexipril.
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