Oroxylin A, a major flavonoid in the extracts of Oroxylum indicum as well as Scutellaria baicalensis possesses useful medicinal properties. Many of the published routes claiming the synthesis of Oroxylin A (1) have in fact led to a regioisomer Negletein (3) that was misinterpreted as Oroxylin A (1). In the present work, we describe a novel, straight-forward and scalable semi-synthetic approach for rapid access to the title compound, the structure of which is unambiguously secured by NMR and X-ray crystallographic analysis of a derivative. This work also encompasses the synthesis of a glycosylated derivative of Oroxylin A viz OAGME (2), which has marked pharmacological importance.

/agrariacad Effect of Booroola fecundity (FeCB) gene on litter size and scope for use in restoration of Nilagiri sheep from threatened status. Efeito do gene Booroola fecundity (FeCB) no escopo e tamanho da ninhada para uso na restauração de ovelhas Nilagiri de status ameaçado

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A Novel Reaction Cascade Leading to a Spontaneous Intramolecular Dipolar Cycloaddition Through Simultaneous Generation of 1,3-Dipole and Dipolarophile. -(KALYANAM*, N.; RAPOLE, K. R.; RAJENDRAN, R.; MAJEED, M.; Tetrahedron Lett. 54 (2013) 38, 5155-5158, http://dx.